Enjoy breakfast at your hotel before the transfer to Ephesus. Wander the ruins of one of the most impressive sites of antiquity. See the impressive amphitheater, remains of the Temple of Hadrian, and Library of Celsus, home to more than 12,000 scrolls in ancient times. The largest collection of Roman ruins in the eastern Mediterranean, Ephesus reveals layers of history, from the archaic, through the classical, Hellenic, Roman and Byzantine eras.
Drive to the Temple of Artemis in the hills of Selcuk, and see the site of one of the 7 Wonders of the Ancient World. Go to the House of the Virgin Mary, thought to be where Mary spent the last years of her life. Take the overnight bus back to Istanbul.